The LA Times reports "In a small, pilot study led by food scientists at Florida State University,   researchers found that eating six grams of watermelon extract a day  for  six weeks lowered blood pressure in all nine middle-aged subjects  with  prehypertension — elevated blood pressure, but not yet considered high blood pressure.
Findings from the pilot study are described in the American Journal of Hypertension.
FSU Assistant Professor Arturo Figueroa, the lead researcher and his  team tested watermelon extract because watermelon is  the richest edible  natural source of L-citrulline, which is closely  related to  L-arginine, an amino acid that's essential to the regulation  of healthy  blood pressure.
Once in the body, the L-citrulline is converted into L-arginine. Simply   consuming L-arginine as a dietary supplement isn't an option for many   hypertensive adults, said Figueroa, because it can cause nausea,   gastrointestinal tract discomfort and diarrhea.
In contrast, watermelon is well tolerated. Participants in the Florida State pilot study reported no adverse effects.
Besides its vascular benefits, watermelon provides abundant vitamin A,   B6, C, fiber, potassium and lycopene, a powerful antioxidant.   Watermelon may even help reduce serum glucose levels, according to   Professor Bahram H. Arjmandi, who also worked on the study.
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